5-Amino-1MQ

Mechanism

5-Amino-1MQ functions by inhibiting NNMT, an enzyme that methylates nicotinamide and thereby reduces available NAD+ pools. By blocking NNMT activity, the compound has been shown in preclinical models to increase intracellular NAD+ concentrations, upregulate sirtuin-mediated metabolic pathways, and promote energy expenditure. In diet-induced obese (DIO) mouse models, this mechanism has been associated with reduced fat mass without changes in food intake, suggesting a direct effect on adipocyte metabolism rather than satiety signaling pathways.

What the literature has looked at

• Studies have investigated its effects on adipose tissue metabolism in DIO mouse models
• Research has examined its role in NAD+ metabolism and sirtuin pathway activation
• Preclinical work has explored NNMT inhibition as a target for metabolic pathway research
• Studies have assessed its effects on cholesterol and lipid profiles in animal models

Research context, not a claim about what this compound does. Research Use Only — not for human or animal consumption. 21+.

Cited work

• Neelakantan H, et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice. Biochem Pharmacol. 2018;147:141-152.

  Research investigated NNMT inhibitor-mediated effects on adipose tissue metabolism in DIO mice, observing changes in body composition and adipose tissue mass over 11 days without alterations in food intake behavior.

• Neelakantan H, et al. Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase. J Med Chem. 2017;60(12):5015-5028.

  Established the SAR for NNMT inhibitors and identified 5-Amino-1MQ as a potent, cell-permeable inhibitor with favorable pharmacological properties.

Properties

molecular Formula

C₁₁H₁₂N₂O

molar Mass

188.23 g/mol

type

Small Molecule