BPC-157

Mechanism

BPC-157 (Body Protection Compound-157) is a 15-amino acid peptide derived from the sequence of human gastric juice protein BPC. Its mechanism of action is multifaceted: it promotes angiogenesis by upregulating vascular endothelial growth factor (VEGF) and its receptors, modulates the nitric oxide (NO) system, and interacts with the dopaminergic, serotonergic, and GABAergic systems. BPC-157 has demonstrated effects on tissue repair mechanisms in tendons, ligaments, muscle, bone, and gastrointestinal mucosa in numerous animal models. It modulates tendon-to-bone repair signaling through increased collagen organization and promotes formation of granulation tissue in preclinical wound models.

What the literature has looked at

• Studies have investigated tendon, ligament, and muscle tissue repair mechanisms in animal models
• Research has examined gastrointestinal mucosal protection and tissue repair signaling
• Studies have explored angiogenic mechanisms through VEGF pathway modulation
• Research has assessed neuroprotective properties and peripheral nerve repair signaling

Research context, not a claim about what this compound does. Research Use Only — not for human or animal consumption. 21+.

Cited work

• Sikiric P, et al. Brain-gut axis and pentadecapeptide BPC 157: theoretical and practical implications. Curr Neuropharmacol. 2016;14(8):857-865.

  Comprehensive review of BPC-157 effects across the brain-gut axis, documenting tissue-repair signaling and protective mechanisms in gastrointestinal, musculoskeletal, and neurological research models.

• Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol. 2011;110(3):774-780.

  Research investigated BPC-157-mediated effects on tendon repair signaling, observing promotion of tendon cell outgrowth, enhanced cell survival under stress, and stimulation of cellular migration pathways.

Properties

type

Peptide (pentadecapeptide, 15 amino acids)