SLU-PP-332

Mechanism

SLU-PP-332 is a synthetic small molecule that selectively activates estrogen-related receptor gamma (ERRgamma), an orphan nuclear receptor highly expressed in metabolically active tissues including skeletal muscle, heart, and brown adipose tissue. ERRgamma regulates the transcription of genes involved in oxidative phosphorylation, fatty acid oxidation, and mitochondrial biogenesis. By activating ERRgamma, SLU-PP-332 has been shown in preclinical models to shift skeletal muscle fiber composition toward oxidative type I fibers, increase mitochondrial content, enhance exercise endurance, and modulate metabolic parameters — effects that partially mimic the adaptations produced by aerobic exercise training.

What the literature has looked at

• Studies have investigated exercise-mimetic effects on skeletal muscle fiber type composition
• Research has examined mitochondrial biogenesis and oxidative metabolism enhancement
• Studies have explored endurance performance effects in sedentary animal models
• Research has assessed metabolic pathway modulation including fat oxidation and glucose handling

Research context, not a claim about what this compound does. Research Use Only — not for human or animal consumption. 21+.

Cited work

• Billon C, et al. Synthetic ERR-alpha/beta/gamma agonist induces an ERR-alpha-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(4):756-771.

  SLU-PP-332 produced an ERR-alpha-dependent acute exercise-like transcriptional response in mouse skeletal muscle and increased running capacity.

• Willy PJ, et al. Regulation of PPARgamma coactivator 1alpha (PGC-1alpha) signaling by an estrogen-related receptor alpha (ERRalpha) ligand. Proc Natl Acad Sci USA. 2004;101(24):8912-8917.

  Foundational work establishing the ERR family as regulators of mitochondrial metabolism and PGC-1alpha signaling, providing the biological basis for ERRgamma-targeted exercise mimetics.